Neem has a long history of relieving inflamed joints, supported by recent scientific studies. Most anti-inflammatories, such as aspirin and ibuprofen, irritate the stomach and may be the major cause for upper GI bellding.

Ulcers sometimes occur as a result of taking too much of these over-the counter drugs. Neem is comparably effective, anti-inflammatory and does not adversely affect the stomach. The active constituents in its leaves relieve pain by acting on the prostaglandin mechanism and significantly reduce acute derma.

Several studies have shown its usefulness with the disease. Some studies have looked at the ability of neem leaf extracts to reduce inflammation. One suggested that the phenolic compounds containing catechin (which possess anti-inflammatory properties) may produce the anti-inflammatory effects. Another investigation found that quercetin, an antibacterial compound, exists in neem leaves. Other studies have shown that the polysaccharides in neem reduce the inflammation and swelling that occur in arthritis. Not only does neem help reduce inflammation; it also has pain suppressing properties. Neem can also help create a balance in the immune system, directly affecting the progression of arthritis.