The Neem has adapted to a wide range of climates. It thrives well in hot weather, where the maximum shade temperature is as high as 49° C and tolerates cold upto 0° C on altitudes upto 1500 m.

Today, the Neem is well established in at least 30 countries world-wide, in Asia, Africa and Central and South America. Some small scale plantations are also reportedly successful in the United States of America.